Jean Baptiste La Moyne and Sieur de Bienville establish the city of New Orleans.

More than 7,000 enslaved Africans occupy French colonial Louisiana and suffer from many endemic diseases of that area.

On November 16, Jean Louis, a French seaman, bequeaths assets to establish the Charity Hospital at New Orleans.

On January 21, the hospital’s charter is recorded.

On May 10, a house on the corner of Chartres and Bienville Streets becomes the first Charity Hospital building.

The second Charity Hospital building is constructed.

A hurricane nearly destroys the second Charity Hospital building.

After receiving King Charles III of Spain’s approval, Don Andres Almonester Y Roxas reconstructs the third Charity Hospital. On October 1, the hospital admits its first patients.

A fire destroys the third Charity Hospital.

The fourth Charity Hospital opens on Canal Street.

The fifth Charity Hospital is constructed.

Tulane University School of Medicine is founded.

The ground area adjacent to the amphitheatre, measuring 247 feet on Tulane Avenue and 430 feet Gravier Street, is expropriated by Charity Hospital; this land acquisition is the beginning of the present “Greater Charity Hospital” of New Orleans.

Huey Long, a flamboyant lawyer from Winnfield, Louisiana, is elected governor of the state of Louisiana. He summons Dr. Arthur Vidrine from Ville Platte, Louisiana, to head Charity Hospital.

On October 1, the LSU School of Medicine opens.

On September 8, Huey P. Long is assassinated. On September 10, he dies.

On July 15, construction begins on a “New” Charity Hospital. The “New” Charity Hospital admits its first patients.

On September 13, Congress enacts the Social Security Amendments.

The Social Security Act establishes Medicare and Medicaid, the most sweeping and far-reaching federal health legislation in American history.

A large number of state health and social services agencies merge into a single Department of Health and Human Resources (DHHR). Charity’s management is split into two positions-a medical director and a hospital administrator.

Lee Frazier, Charity Hospital’s first African-American administrator, is appointed.

Governor Edwin Edwards appoints Elliott Roberts as Charity administrator.

Citizens elect David Treen, a conservative Republican, as governor of the state. The secretary of DHHR, at Treen’s direction, appoints Charles Lazarre as Charity administrator.

Governor Edwards is re–elected re–appoints Elliott Roberts as Charity administrator.

Act 855 of the Legislature establishes LHCA as a public governmental entity and a freestanding political subdivision of the state.

Act 390 of the Legislature transfers nine hospitals from DHHR (later renamed Department of Health and Hospitals) and places them under the management of LHCA.

On January 1, LHCA assumes managerial responsibility of the nine acute-care public hospitals.

The Daughters of Charity sell Hotel Dieu Hospital to the state, at the request of Governor Edwin Edwards’ administration. The institution later changes name to University Hospital.

Charity and University Hospitals merge to form the Medical Center of Louisiana at New Orleans (MCLNO). LHCA appoints Jonathan Roberts as the first CEO.

Act 3 of the Louisiana Legislature transfers the Charity Hospital System from LHCA to LSU.